As of my last knowledge update, Barry Bonds holds the record for the most career home runs in Major League Baseball, with a total of 762 home runs. This record was set during his career, primarily with the San Francisco Giants, marking him as one of the most prominent figures in the sport’s history. Bonds' achievement has drawn significant attention, both for his remarkable talent and the controversy surrounding performance-enhancing drugs. His record remains a topic of discussion and debate among baseball enthusiasts.