The maximum score possible in a game of ten-pin bowling is 300. This is achieved by bowling a perfect game, where a player scores strikes in all 12 frames, resulting in a total of 12 strikes. Each strike is worth 10 points plus the total points from the next two rolls, which compounds the score to its maximum potential. Perfect games are rare and are celebrated within the bowling community, marking a significant accomplishment for bowlers demonstrating skill and consistency.