The highest score obtained in a single-frame bowling session is a perfect score of 300. To achieve this, a bowler must roll 12 consecutive strikes in one game, resulting in the maximum score possible in ten frames. Each strike scores ten points, plus the points from the next two rolls, thus accumulating the maximum total. Achieving a 300 is considered a significant accomplishment in bowling, showcasing the bowler's skill, precision, and consistency throughout the game.