The organ responsible for detoxifying alcohol in the body is the liver. The liver metabolizes alcohol through a series of enzymatic reactions, primarily involving enzymes like alcohol dehydrogenase. This process converts alcohol into safer substances that can then be eliminated from the body. The liver plays a crucial role in maintaining homeostasis and regulating blood chemical levels, making it essential for overall health. Chronic alcohol consumption can lead to liver damage, such as cirrhosis or fatty liver disease.