The significance of cellular signaling in immune responses lies in its ability to coordinate and activate various immune cells in response to pathogens. Signaling molecules, such as cytokines and chemokines, facilitate communication between immune cells, enabling them to respond appropriately to infections. This process is crucial for the differentiation of immune cells, triggering inflammation, and developing long-term immunity. Disruptions in signaling pathways can lead to immune deficiencies or autoimmune diseases, emphasizing its importance in maintaining health.