The significance of bioinformatics in biotechnology lies in its ability to analyze and interpret complex biological data, such as genomic sequences. By employing computational tools, bioinformatics supports research in genetics, genomics, and proteomics, facilitating advancements in areas like drug development, personalized medicine, and agricultural biotechnology. Its applications enhance our understanding of biological processes and diseases, enabling researchers to make informed decisions based on data-driven insights, ultimately driving innovation in life sciences.