To achieve statistical significance in research, researchers typically use a statistical test to determine whether observed results are likely due to chance. This involves assigning a p-value, which quantifies the probability that the results would occur under the null hypothesis. A common threshold for significance is a p-value of less than 0.05, suggesting that the likelihood of observing the results due to random chance is low. By establishing a confidence level, researchers can ascertain whether their findings are meaningful and can be used to draw conclusions regarding relationships between variables.