The primary reason for the development of antibiotic resistance in bacteria is the misuse and overuse of antibiotics. When antibiotics are used excessively or inappropriately, bacteria may be exposed to sublethal doses, allowing some to survive and develop mutations that confer resistance. These resistant bacteria can proliferate, leading to the emergence of strains that are difficult to treat, presenting significant public health challenges. Effective antibiotic stewardship and responsible prescription practices are crucial to combatting this issue.