The main role of the skeletal system in humans is to provide structure, support, and protection to the body. It consists of bones, cartilage, ligaments, and joints that work together to form the framework for the human body. The skeletal system also plays a crucial role in movement by allowing muscles to attach and exert force. Additionally, it houses the bone marrow, where blood cells are produced, and stores essential minerals such as calcium and phosphorus, contributing to overall health and stability.