The main responsibility of the endocrine system is to regulate various bodily functions through the secretion of hormones. This system comprises glands such as the pituitary, thyroid, and adrenal glands, which release hormones into the bloodstream to communicate with target organs and tissues. These hormones are involved in regulating processes such as metabolism, growth, reproduction, and the body’s response to stress. Overall, the endocrine system plays a vital role in maintaining homeostasis.