The main reason for the depletion of the ozone layer is the release of chlorofluorocarbons (CFCs) and other ozone-depleting substances into the atmosphere. These chemicals, once commonly used in refrigeration, aerosol sprays, and foam production, rise into the stratosphere. There, they break down under ultraviolet (UV) radiation, releasing chlorine atoms that catalyze the destruction of ozone molecules. This depletion leads to increased UV radiation reaching Earth's surface, resulting in harmful effects like skin cancer, cataracts, and negative impacts on ecosystems.