The main challenge of combating antibiotic resistance is the rapid adaptation of bacteria to evade the effects of antibiotics. Overuse and misuse of antibiotics in both medical and agricultural settings accelerate this resistance process. As resistant strains proliferate, conventional treatments become less effective, leading to longer illnesses, increased medical costs, and a higher mortality rate. Addressing this challenge requires a multifaceted approach, including improved antibiotic stewardship, increased research into new medications, and enhancing infection prevention tactics to mitigate the spread of resistant bacteria within populations.