The concept of negative feedback in biological systems refers to a regulatory mechanism where the output of a process inhibits or dampens the initial stimulus. This mechanism maintains homeostasis, ensuring stable internal conditions despite external fluctuations. For instance, in thermoregulation, if body temperature rises, mechanisms are activated to cool the body down, restoring balance. Negative feedback loops are crucial in various physiological processes, such as hormone regulation and metabolic control, contributing to the overall stability and functionality of biological organisms.