The major political event associated with the slogan "Hope and Change" is the presidential campaign of Barack Obama in 2008. This phrase encapsulated the message of the Obama campaign, emphasizing a promise to uplift the nation and instigate meaningful reforms in various areas, such as healthcare, economic recovery, and foreign policy. The slogan resonated with many voters who sought a departure from previous administration policies and a fresh approach to governance. The campaign's success reflected a pivotal moment in U.S. politics, highlighting the electorate's desire for progress and revitalization.