The Equal Protection Clause of the 14th Amendment prohibits states from denying any person equal protection under the law. This clause is crucial for advancing civil rights, ensuring that individuals are treated equally regardless of race, gender, or class. Its significance is highlighted in landmark Supreme Court cases that challenged discriminatory laws and practices, paving the way for greater social justice. The clause serves as a legal foundation for fighting inequality and discrimination, reinforcing the principles of democracy and fairness within the legal framework of the United States.