The responsibilities of the Secretary of State in the U.S. government encompass managing the country’s foreign affairs and representing the U.S. to other nations. The Secretary oversees the State Department, which formulates and implements diplomatic policies, negotiates treaties, and engages in international relations. This role also involves advising the President on foreign matters, managing U.S. embassies, and ensuring the protection of American citizens abroad. Overall, the Secretary of State plays a crucial role in shaping U.S. foreign policy.