The theme prevalent in the myth of Pandora's box is the idea of curiosity and its consequences. Pandora, crafted by the gods, is given a box with strict instructions not to open it. Her curiosity ultimately leads to the release of all the world's evils, leaving only hope inside. This myth illustrates how human nature can lead to unintended repercussions, mirroring the struggle between knowledge and innocence. The story encourages caution regarding the pursuit of forbidden knowledge and emphasizes that while evils exist, the enduring presence of hope provides a counterbalance to human struggles.