The phrase "Give me liberty, or give me death" was famously declared by Patrick Henry during a speech he delivered to the Second Virginia Convention on March 23, 1775. This powerful oration aimed to rally support for the revolutionary cause against British rule. Henry's passionate plea highlighted the desire for freedom and resistance against oppression, encapsulating the sentiments that motivated the American colonies in their struggle for independence. His speech is considered a pivotal moment in American history, inspiring many to join the fight for liberty and ultimately shaping the nation’s quest for independence.