The quote "Give me liberty, or give me death" is best known for being stated by Patrick Henry. He delivered this powerful line in a speech to the Second Virginia Convention in 1775, expressing his belief that the American colonies should seek independence from British rule. Henry's impassioned argument emphasized the importance of freedom and the willingness to fight for it, contrasting the idea of living under tyranny with the noble pursuit of liberty. This speech was pivotal in galvanizing support for the Revolutionary War, setting the stage for the eventual fight for independence.