The major conflict that erupted in the 18th century stemming from colonial rivalry was the French and Indian War, also known as the Seven Years' War. Fought from 1754 to 1763, this conflict involved Great Britain and its colonies against France and various Native American allies. The war primarily centered on territorial disputes over land in North America, particularly in the Ohio River Valley. The British victory significantly altered the balance of power in North America, leading to increased tensions between Britain and its colonies due to the rising costs of war debt, which ultimately contributed to the American Revolution.