The historical figure known for the quote, "Give me liberty, or give me death!" is Patrick Henry. He was an influential American statesman and orator from Virginia, who played a crucial role in the American Revolution. Henry delivered this quote during a speech at the Second Virginia Convention in 1775, expressing his fervent belief in the necessity of fighting for freedom from British rule. His passionate rhetoric galvanized support for the revolutionary cause and highlighted the urgency of resistance against oppression. His famous speech remains a symbol of American patriotism and the struggle for liberty.