The historical figure known for the quote "Give me liberty, or give me death" is Patrick Henry. He delivered this famous statement during a speech at the Second Virginia Convention in 1775. Henry's passionate plea emphasized the urgency of taking arms against British rule in the colonies and underscored the desire for independence. His oratory skills inspired many to join the fight for liberty, helping to galvanize support for the American Revolution. The phrase has since become emblematic of the spirit of freedom and resistance against tyranny in American history.