The Mayflower left from England in 1620. This ship famously carried a group of Pilgrims, a congregation of English Separatists seeking to escape religious persecution and establish a new life in the New World. After a challenging journey across the Atlantic, they landed at Plymouth Rock, in present-day Massachusetts, where they established one of the first English colonies in North America. The Mayflower's voyage is significant in American history, symbolizing the quest for religious freedom and the early beginnings of what would become the United States.