The turning point in the American Civil War characterized by a significant battle in Pennsylvania was the Battle of Gettysburg, fought from July 1 to July 3, 1863. This battle is often considered the war's pivotal encounter, marking a crucial defeat for the Confederate Army led by General Robert E. Lee. The Union victory, commanded by General George Meade, ended Lee's invasion of the North and boosted Northern morale. The battle also resulted in high casualties, with approximately 51,000 soldiers killed, wounded, or missing. The Union's success at Gettysburg, combined with the Siege of Vicksburg occurring simultaneously, marked the beginning of a series of Union advances that ultimately led to victory.