The significance of the Voting Rights Act of 1965 lies in its role in strengthening American democracy by prohibiting racial discrimination in voting. This landmark legislation aimed to eliminate barriers, such as literacy tests and poll taxes, that were used to disenfranchise African American voters. It empowered the federal government to oversee voter registration in areas with a history of discriminatory practices. By ensuring equal access to the polls, the Act not only advanced civil rights but also reinforced the principle of universal suffrage, helping to reshape the political landscape and promote a more inclusive democracy.