The significance of the U.S. Constitution's Bill of Rights lies in its protection of individual liberties and rights against governmental overreach. Ratified in 1791, it consists of the first ten amendments, which secure fundamental freedoms such as freedom of speech, religion, and the right to a fair trial, among others. The Bill of Rights was essential in addressing concerns from anti-Federalists who feared that the new Constitution would grant too much power to the federal government. Its establishment helped secure broader support for the Constitution, and it remains a cornerstone of American democracy, influencing legal frameworks globally.