The significance of the Prohibition Amendment, formally known as the 18th Amendment, was profound as it aimed to eliminate alcohol consumption in the United States. Ratified in 1919 and enforced by the Volstead Act, Prohibition was intended to improve society by reducing crime, corruption, and health issues associated with alcohol. Instead, it led to unintended consequences, including the rise of organized crime, speakeasies, and widespread disregard for the law. Ultimately, its negative effects culminated in its repeal in 1933 with the 21st Amendment, highlighting the challenges of legislating morality and the complexity of social reforms.