The significance of the Cheyenne and Lakota's resistance to U.S. westward expansion lies in their demonstration of Indigenous resilience and the struggle for land rights. Their confrontations, especially in events such as the Battle of Little Bighorn, symbolized the fierce opposition to encroachment and oppression brought by U.S. settlers. This resistance highlighted the broader conflict between Native American tribes and the U.S. government, encapsulating themes of colonialism and cultural survival. Ultimately, this struggle underscored the ongoing impact of westward expansion on Indigenous communities, shaping perceptions of sovereignty and rights in America today.