The primary cause of the 1857 uprise in India against the British was widespread resentment towards British colonial rule and cultural insensitivity. This uprising, known as the **Sepoy Mutiny** or the **First War of Independence**, was sparked by various factors, including grievances over the introduction of the Enfield rifle, which utilized animal fat for lubrication, offending both Hindu and Muslim sepoys. Economic exploitation and oppressive policies further inflamed anger towards the British. The uprising marked a significant moment in Indian history, leading to the dissolution of the British East India Company and direct British government control over India.