The outcome of the conflict between the U.S. and Native American tribes resulted in significant territorial and cultural loss for Native populations. Throughout the 19th century, U.S. expansionist policies, driven by the ideology of Manifest Destiny, led to forced removals and the signing of treaties, many of which were later broken. The Indian Removal Act of 1830 exemplified this trend, resulting in the Trail of Tears, where thousands of Native Americans were displaced. This conflict and its aftermath decimated populations and disrupted traditional ways of life, fundamentally altering the cultural landscapes of indigenous nations and leading to ongoing struggles for recognition and rights.