The Great Schism, which occurred in 1054, significantly impacted the Christian church by creating a major division between Eastern Orthodoxy and Roman Catholicism. The primary issues included disputes over papal authority and theological differences, notably concerning the filioque clause in the Nicene Creed. This schism not only led to the establishment of two separate churches but also set the stage for religious conflicts and cultural divergence between Eastern and Western Europe. The divide has persisted for centuries, affecting everything from political alliances to cultural practices, and remains a focal point in discussions of Christian unity today.