The historical significance of the Treaty of Ghent lies in its role in ending the War of 1812 between the United States and Great Britain. Signed in 1814, the treaty effectively restored relations to their pre-war status, thus negating territorial gains by either side. It marked an important moment for the young United States, confirming its independence and paving the way for improved US-British relations. The treaty is seen as a step toward fostering a spirit of peace and cooperation between the two nations.