The historical significance of the Pilgrims arriving in America in 1620 lies in their role in establishing one of the first successful English settlements in North America, Plymouth Colony. They sought religious freedom and a new start away from the Church of England, embodying the quest for liberty that would later be a cornerstone of American values. The Pilgrims' journey was marked by perseverance and hardship, and their interactions with Indigenous peoples, including the Wampanoag tribe, led to early forms of cooperation and cultural exchange. This event is celebrated in the U.S. during Thanksgiving, symbolizing resilience and community.