The cultural significance of the Great Plains Wars in American history lies in their representation of the conflict between Native American tribes and the U.S. government amidst westward expansion. These conflicts included battles and skirmishes from the mid-19th century to the early 20th century, as settlers encroached on indigenous lands. The wars starkly illustrated the struggles of Native peoples to resist displacement and cultural erasure, leading to devastating consequences. The Great Plains Wars also played a pivotal role in shaping U.S. policy toward Native Americans, contributing to ongoing debates about sovereignty, civil rights, and cultural survival.