The notable international agreement aimed at regulating the trade of human trafficking in the 20th century is the Protocol to Prevent, Suppress and Punish Trafficking in Persons, also known as the Palermo Protocol. Adopted by the United Nations in 2000, it established a comprehensive framework to combat trafficking by promoting international cooperation and adopting measures to protect victims while holding traffickers accountable. The agreement represented a significant commitment by the global community to address this grave human rights violation and enhance protective measures against exploitation.