The major uprising that occurred in 1776, leading to a shift in American governance, was the American Revolution. Sparked by rising discontent with British taxation and lack of representation, the colonies united to fight against British authority. The Declaration of Independence, signed on July 4, 1776, declared the colonies' intention to break free and establish a new nation founded on principles of liberty and self-governance. This revolution not only led to the establishment of the United States but also influenced revolutionary movements worldwide, promoting ideals of democracy and independence.