The famous speech President Franklin D. Roosevelt presented during the Great Depression was his inaugural address on March 4, 1933, famously known for the line "the only thing we have to fear is fear itself." In this speech, Roosevelt aimed to reassure Americans amid economic turmoil, outlining his commitment to combating the Great Depression through government intervention and reform. He emphasized the need for collective effort and resilience to restore confidence and stability in the country. This address marked the beginning of his New Deal policies, which sought to provide relief, recovery, and reform to improve economic conditions.