The U.S. state that has the Great Smoky Mountains is Tennessee. This mountain range, part of the Appalachian Mountains, is renowned for its biodiversity, rich history, and stunning landscapes. The Great Smoky Mountains National Park, the most visited national park in the United States, features diverse ecosystems, wildlife, and scenic vistas. The park serves as a refuge for various plant and animal species and offers extensive opportunities for outdoor activities such as hiking, camping, and wildlife viewing. The natural beauty of the area makes it a beloved destination.