The major river that flows through New Orleans is the Mississippi River. This iconic river is one of the longest in North America, running from Minnesota to the Gulf of Mexico. New Orleans lies near its mouth, where the river meets the sea, playing a crucial role in the city’s culture, economy, and history. The Mississippi River is vital for trade, transportation, and agriculture, serving as a waterway for goods and people throughout its course, and profoundly influencing the region's development.