The relative location of the Nile in relation to the Sahara Desert is that it flows through and along the western edge of the Sahara. The Nile is the world's longest river, running through several countries, including Uganda, Sudan, and Egypt, before emptying into the Mediterranean Sea. Its waters provide a crucial lifeline in the arid desert environment, facilitating agriculture and supporting civilizations like ancient Egypt. The contrast between the lush Nile Valley and the surrounding arid Sahara emphasizes the river's significance in sustaining human life and culture in the region.