The major river that runs through New Orleans, Louisiana, is the Mississippi River. It is one of the longest rivers in North America, playing a crucial role in the region's economy and culture. The river is vital for shipping and trade and has shaped the history of the city and the surrounding areas. Its delta is known for rich biodiversity and is critical for wetlands and wildlife. The Mississippi also famously features in literature and music, making it a significant cultural icon for New Orleans and beyond.