The major river that flows through the city of Cairo is the Nile River. Renowned as one of the longest rivers in the world, it has sustained human civilization for thousands of years. The Nile is crucial for agriculture in Egypt, providing fertile soil through its annual floods. It flows northward, eventually emptying into the Mediterranean Sea. The river is central to Egyptian culture and history, with several ancient sites located along its banks, symbolizing the heart of ancient Egyptian civilization.