The large body of water that lies between **Africa** and **Europe** is the **Mediterranean Sea**. This sea serves as a vital link between numerous countries, facilitating trade and cultural exchange throughout history. The Mediterranean is renowned for its rich biodiversity and distinct ecosystems, hosting a variety of marine life. Its coastlines are home to many ancient civilizations, from the Greeks to the Romans, making it historically significant. Additionally, the climate of the Mediterranean region supports diverse agriculture, contributing to its economic and cultural importance to the surrounding nations.