The largest lake in South America is Lago Titicaca. Located on the border of Peru and Bolivia, it is also considered the highest navigable lake globally, situated at an elevation of approximately 3,812 meters (12,507 feet) above sea level. Lago Titicaca is an important cultural site, home to various indigenous groups, including the Uros, known for their floating reed islands. The lake supports diverse wildlife and is a vital resource for local economies, emphasizing its ecological and cultural significance.