The organ responsible for detoxifying substances in the body is the liver. It plays a critical role in processing nutrients and filtering harmful toxins from the bloodstream. The liver converts substances like alcohol and drugs into less harmful compounds that can be eliminated from the body. It also produces bile, which aids in digestion and helps break down fats. Additionally, the liver stores essential nutrients, such as vitamins and glycogen, and contributes to metabolic processes. Its ability to regenerate itself makes the liver a vital organ, but excessive damage can lead to severe health issues, emphasizing the importance of liver health.