The Shakespearean play featuring the characters Ophelia and Hamlet is "Hamlet." This tragedy, written between 1599 and 1601, explores themes of revenge, madness, and existentialism. Ophelia is a key character who struggles with the demands of her father, Polonius, and her relationship with Hamlet, the play’s protagonist. Ophelia’s descent into madness, following the death of her father and her tumultuous relationship with Hamlet, leads to her tragic demise. The interplay between Hamlet and Ophelia highlights the complexities of love, duty, and the consequences of political intrigue.