Leonardo da Vinci's most famous painting is the "Mona Lisa." Housed in the Louvre Museum in Paris, this iconic artwork has captivated audiences since it was completed in the early 16th century. The painting is celebrated for its exquisite detail, enigmatic expression, and innovative use of sfumato, a technique that creates soft transitions between colors and tones. The subject, Lisa Gherardini, is thought to be the wife of a Florentine merchant, and her mysterious smile has sparked numerous interpretations and discussions over the centuries. The "Mona Lisa" remains one of the most recognized and revered paintings in the world.