The organ primarily responsible for detoxifying substances in the body is the liver. The liver plays a critical role in metabolizing nutrients, producing bile for digestion, and filtering blood to remove toxins and waste products. It processes medications and converts harmful substances into less toxic compounds that can be excreted through urine or bile. The liver also stores essential nutrients and vitamins, facilitating their release into the bloodstream as needed. Due to its vital functions and capacity to regenerate, maintaining liver health is crucial for overall well-being and the body's ability to detoxify effectively.