The primary organ responsible for detoxification in the human body is the liver. This crucial organ processes blood coming from the digestive tract, breaking down harmful substances, metabolizing drugs, and filtering toxins. The liver plays a vital role in maintaining homeostasis by regulating chemicals and producing bile to aid digestion. Additionally, it synthesizes proteins necessary for blood clotting and other vital functions. Overall, the liver's detoxifying capabilities are essential for ensuring that harmful substances do not accumulate in the body, thereby protecting overall health and allowing for normal bodily functions.