The organ in the body responsible for detoxification is the liver. It plays a crucial role in metabolizing and processing substances, breaking down toxins and waste products from the bloodstream. The liver filters blood coming from the digestive tract, metabolizing nutrients and expelling harmful substances, including drugs and alcohol. Additionally, it produces bile, which helps in digestion and absorption of fats. The liver also stores various nutrients, regulates blood sugar levels, and produces proteins essential for blood clotting. Overall, its detoxifying functions are vital for maintaining overall health and homeostasis within the body.